Many drugs have poor water solubility and for oral delivery of such drugs are usually associated with limitation of low bioavailability. Develop a stable micellar formulation for poorly water soluble drugs having an excellent capacity to increase solubilization and bioavailability. The aim of study was to develop micelles formulation for oral delivery of norfloxacin. Developed micelle contains a lipophilic drug norfloxacin, using Pluronic F-68 prepared by Sonication method. They were characterized for FTIR, XRD, SEM, stability and solubility. The peaks of drugs and polymer were found in FTIR analysis shows there were no interaction between drug and polymer. XRD diffractogram of norfloxacin shows characteristic crystalline peaks at 13.250°, 20.780°, 25.090°. The XRD diffractograms of polymeric micelles shows the same characteristic crystalline peaks at 13.250°, 20.780°, 25.090° but with less intensity. SEM studies revealed surface morphology and size reduction of norfloxacin in formulated batches. Solubility of formulation was found to be in the range of 0.246 to 0.710 % release of norfloxacin. Out of 9 formulated batches, formulation TMM 5 released maximum 0.710% and formulation TMM 7 released minimum 0.246% of drug. Absence of turbidity in the solution between 1.2 to 3 as well as microscopy of the filter suggested that there was no aggregation or precipitate of the micelles. This suggests micelles were stable in the acidic pH. It was concluded that the micelles drug delivery of norfloxacin showed a better solubility, stability of micelles. Prepared polymeric micelles system can be used as a prospective delivery carrier for norfloxacin.
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